Selected papers

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.

Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wünnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JS. JCI Insight. 2022 Mar 22;7(6):e154174. doi: 10.1172/jci.insight.154174.PMID: 35167498

Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes.

Raggi C, M'Callum MA, Pham QT, Gaub P, Selleri S, Baratang NV, Mangahas CL, Cagnone G, Reversade B, Joyal JS, Paganelli M. Stem Cell Reports. 2022 Mar 8;17(3):584-598. doi: 10.1016/j.stemcr.2022.01.003. Epub 2022 Feb 3.PMID: 35120625

eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.

Smith TL, Oubaha M, Cagnone G, Boscher C, Kim JS, El Bakkouri Y, Zhang Y, Chidiac R, Corriveau J, Delisle C, Andelfinger GU, Sapieha P, Joyal JS, Gratton JP.Cell Mol Life Sci. 2021 Dec 31;79(1):37. doi: 10.1007/s00018-021-04042-y.PMID: 34971428

Cardiac Left Ventricle Mitochondrial Dysfunction After Neonatal Exposure to Hyperoxia: Relevance for Cardiomyopathy After Preterm Birth.

Ravizzoni Dartora D, Flahault A, Pontes CNR, He Y, Deprez A, Cloutier A, Cagnone G, Gaub P, Altit G, Bigras JL, Joyal JS, Mai Luu T, Burelle Y, Nuyt AM.Hypertension. 2021 Dec 28:HYPERTENSIONAHA12117979. doi: 10.1161/HYPERTENSIONAHA.121.17979. Online ahead of print.PMID: 34961326

Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.

Brais-Brunet S, Heckel É, Kanniyappan U, Chemtob S, Boudoux C, Joyal JS, Dehaes M.Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):20. doi: 10.1167/iovs.62.13.20.PMID: 34698774 

Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies.

Othman R, Cagnone G, Joyal JS, Vaucher E, Couture R.Cells. 2021 Jul 28;10(8):1913. doi: 10.3390/cells10081913.PMID: 34440682 

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation.

Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A.

Dev Cell. 2021 Jul 12:S1534-5807(21)00528-1. doi: 10.1016/j.devcel.2021.06.021. Online ahead of print.

PMID: 34273276

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration.

Fu Z, Qiu C, Cagnone G, Tomita Y, Huang S, Cakir B, Kotoda Y, Allen W, Bull E, Akula JD, Joyal JS, Hellström A, Talukdar S, Smith LEH.

iScience. 2021 Mar 29;24(4):102376. doi: 10.1016/j.isci.2021.102376. eCollection 2021 Apr 23.

PMID: 33937726

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O'Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P.

Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5.

PMID: 33548171

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration.

Dabouz R, Cheng CWH, Abram P, Omri S, Cagnone G, Sawmy KV, Joyal JS, Desjarlais M, Olson D, Weil AG, Lubell W, Rivera JC, Chemtob S.J Neuroinflammation. 2020 Nov 27;17(1):359. doi: 10.1186/s12974-020-02032-8.

PMID: 33246504

Vitreous metabolomics profiling of proliferative diabetic retinopathy.

Tomita Y, Cagnone G, Fu Z, Cakir B, Kotoda Y, Asakage M, Wakabayashi Y, Hellström A, Joyal JS, Talukdar S, Smith LEH, Usui Y.

Diabetologia. 2021 Jan;64(1):70-82. doi: 10.1007/s00125-020-05309-y. Epub 2020 Oct 25.

PMID: 33099660

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.

Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F,       Joyal JS*, Mallette FA*, Sapieha P*. (*Co-corresponding authors)

Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356.

PMID: 32820093

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation.

Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A.

Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z.

PMID: 32807793

Fulminant Necrotizing Enterocolitis and Multiple Organ Dysfunction in a Toddler with Mitochondrial DNA Depletion Syndrome-13.

Nardi N, Proulx F, Brunel-Guiton C, Oligny LL, Piché N, Mitchell GA, Joyal JS.

J Pediatr Intensive Care. 2020 Mar;9(1):54-59. doi: 10.1055/s-0039-1697620. Epub 2019 Oct 10.

PMID: 31984159 

Should We Care About Pediatric Multiple Organ Dysfunction Syndrome?

Proulx F, Joyal JS, Lacroix J.

Pediatr Crit Care Med. 2019 Oct;20(10):987-988. doi: 10.1097/PCC.0000000000002066.

PMID: 31580273 

Immunometabolic modulation of retinal inflammation by CD36 ligand.

Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Pundir S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H.

Sci Rep. 2019 Sep 9;9(1):12903. doi: 10.1038/s41598-019-49472-8.

PMID: 31501473

Dyslipidemia in retinal metabolic disorders.

Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellström A, Joyal JS, Smith LE.

EMBO Mol Med. 2019 Oct;11(10):e10473. doi: 10.15252/emmm.201910473. Epub 2019 Sep 5.

PMID: 31486227

Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Madaan A, Chaudhari P, Nadeau-Vallée M, Hamel D, Zhu T, Mitchell G, Samuels M, Pundir S, Dabouz R, Howe Cheng CW, Mohammad Nezhady MA, Joyal JS, Rivera JC, Chemtob S.

Am J Pathol. 2019 Sep;189(9):1878-1896. doi: 10.1016/j.ajpath.2019.05.016. Epub 2019 Jun 18.

PMID: 31220454

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.

PMID: 30787185 

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

Beaudry-Richard A, Nadeau-Vallée M, Prairie É, Maurice N, Heckel É, Nezhady M, Pundir S, Madaan A, Boudreault A, Hou X, Quiniou C, Sierra EM, Beaulac A, Lodygensky G, Robertson SA, Keelan J, Adams Waldorf KM, Olson DM, Rivera JC, Lubell WD, Joyal JS, Bouchard JF, Chemtob S.

Sci Rep. 2018 Aug 8;8(1):11875. doi: 10.1038/s41598-018-30087-4.

PMID: 30089839

Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism.

Joyal JS*, Gantner ML, Smith LEH*. (*Co-corresponding authors)

Prog Retin Eye Res. 2018 May;64:131-156. doi: 10.1016/j.preteyeres.2017.11.002. Epub 2017 Nov 22. Review. No abstract available.

PMID: 29175509

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Joyal JS*, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, et al. (*Co-corresponding authors)

Nat Med. 2016 Apr;22(4):439-45. doi: 10.1038/nm.4059. Epub 2016 Mar 14.

PMID: 26974308

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Joyal JS*, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, et al. (*Co-corresponding authors)

Nat Med. 2014 Oct;20(10):1165-73. doi: 10.1038/nm.3669. Epub 2014 Sep 14.

PMID: 25216639

SOCS3 is an endogenous inhibitor of pathologic angiogenesis.

Stahl A* , Joyal JS*, Chen J, Sapieha P, Juan A M, et al. (co-first author)

Blood, 2012 Oct 4;120(14):2925-9.

PMID: 22791286

Ischemic neurons prevent vascular regeneration of neural tissue by secreting Semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, et al.

Blood, 2011 Jun 2;117(22):6024-35. 

PMID: 21355092

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.

Sapieha P, Joyal JS, Rivera JC,  Kermorvant-Duchemin E, Sennlaub F, et al.

J Clin Invest. 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.

PMID: 20811158

The succinate receptor GPR91 present on neurons, exerts a major role in retinal angiogenesis.

Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, et al.

Nature Medicine 2008 Oct;14(10):1067-76.

PMID: 18836459