Researcher: Jean-Sébastien Joyal, MD, PhD
Duration: 4-6 years
Starting date: Winter/summer 2021
Our laboratory explores the role of neuronal energy metabolism in physiologic and pathologic angiogenesis. Understanding the drivers of abnormal vessel growth is key to controlling many diseases of the eye and cancer. In the retina, oxygen and energy demands of neurons govern in part blood vessel development. Although much is known about oxygen drivers of angiogenesis, surprisingly little is known about the neuronal energy signals that are also likely to control vessel growth.
We use transgenic mice to study the driver of angiogenesis in models of proliferative retinopathy and age-related macular degeneration (AMD), together the leading cause of blindness. The eye is part of the central nervous system and consumes more energy than any other organ. It is therefore an excellent model in which to explore the metabolic crosstalk between neurons and vessels to discover new therapeutic targets.
Requirements and Skills
Qualified candidates will be trained with various laboratory techniques including retinal dissection, confocal microscopy imaging, laser-capture micro-dissection, real-time PCR, cell culture and mouse colony maintenance.
We generate iPS from human fibroblast with rare genetic metabolic disorders to explore our questions. Prior skills with iPS would be an asset.
B.Sc. or graduate degree in biology or related fields with excellent academic standing
Experience in laboratory work preferred
Highly motivated candidates considering a career in research or medicine
Please submit your CV, transcripts, a letter of introduction and 3 references.
To: Jean-Sébastien Joyal, MD, PhD
Submit CV to Gael Cagnone (email@example.com)