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Researcher:              Jean-Sébastien Joyal, MD, PhD

 

Position:                    PhD/Post-doc                                   

Duration:                   4-6 years

Starting date:           Winter/summer 2024

 

Project

Our laboratory explores the role of neuronal energy metabolism in physiologic and pathologic angiogenesis. Understanding the drivers of abnormal vessel growth is key to controlling many diseases of the eye and cancer. In the retina, oxygen and energy demands of neurons govern in part blood vessel development. Although much is known about oxygen drivers of angiogenesis, surprisingly little is known about the neuronal energy signals that are also likely to control vessel growth.

 

We use transgenic mice to study the driver of angiogenesis in models of proliferative retinopathy and age-related macular degeneration (AMD), together the leading cause of blindness. The eye is part of the central nervous system and consumes more energy than any other organ. It is therefore an excellent model in which to explore the metabolic crosstalk between neurons and vessels to discover new therapeutic targets.

 

Requirements and Skills

Qualified candidates will be trained with various laboratory techniques including retinal dissection, confocal microscopy imaging, laser-capture micro-dissection, real-time PCR, cell culture and mouse colony maintenance.

 

We generate iPS from human fibroblast with rare genetic metabolic disorders to explore our questions. Prior skills with iPS would be an asset.

 

  • B.Sc. or graduate degree in biology or related fields with excellent academic standing

  • Experience in laboratory work preferred

  • Highly motivated candidates considering a career in research or medicine

 

Please submit your CV, transcripts, a letter of introduction and 3 references.

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To:      Jean-Sébastien Joyal, MD, PhD

Submit CV to js.joyal@umontreal.ca

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